Inhibitors of focal adhesion kinase

Details Inhibitors of focal adhesion kinase Inhibitors of focal adhesion kinase

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2681015

The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

L'invention concerne des inhibiteurs de kinase d'adhérence focale, enzyme impliquée dans la fixation du cytosquelette d'une cellule sur une matrice extracellulaire, impliquée dans des processus tels que la migration de cellules, la prolifération de cellules et la survie de cellules. Les inhibiteurs sont des dérivés de 2,4-diaminopyridine 5-substituée, où les substituants sont tels que définis ci-dessus. L'invention fournit également un procédé d'utilisation des inhibiteurs dans le traitement du cancer ainsi que des procédés de préparation des inhibiteurs par l'utilisation de réactions d'accouplement.

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