Inhibitors of glycogen synthase kinase 3

Details Inhibitors of glycogen synthase kinase 3 Inhibitors of glycogen synthase kinase 3

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) C07D 213/85 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2502819

New carbocyclic compounds of formula (I), compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease, other neurodegenerative disorders, such as Parkinson's disease and Huntington's disease, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

L'invention concerne de nouveaux composés carbocycliques selon la formule (I), des compositions et des procédés d'inhibition de l'activité du glycogène synthase kinase (GSK3) in vitro et de traitement de troubles attribués au GSK3 in vivo. Les procédés, composés et compositions selon l'invention peuvent être utilisés seuls, ou en combinaison avec d'autres agents pharmacologiquement actifs dans le traitement de troubles occasionnés par l'activité de GSK, tels que dans le traitement de diabètes, maladie d'Alzheimer, autres troubles neurodégénératifs, tels que maladie de Parkinson et maladie d'Huntington, obésité, maladies cardiovasculaires athéroscléreuses, hypertension essentielle, syndrome de Stein-Leventhal, syndrome X, ischémie, traumatisme cérébral, maladie affective bipolaire, immunodéficience ou cancer.

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