Inhibitors of h+k+-atpase

Details Inhibitors of h+k+-atpase Inhibitors of h+k+-atpase

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 47/48 (2006.01) C07C 233/36 (2006.01) C07C 233/78 (2006.01) C07C 237/24 (2006.01) C07C 271/20 (2006.01) C07C 335/08 (2006.01) C07C 335/32 (2006.01) C07D 207/333 (2006.01) C07D 211/58 (2006.01) C07D 215/56 (2006.01) C07D 233/90 (2006.01) C07D 235/30 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 473/00 (2006.01) C07D 473/34 (2006.01) C07D 475/04 (2006.01) C07D 47

Patent

CA 2319477

Disclosed are multibinding compounds which inhibit H+/K+-ATPase, an enzyme which is involved in the control of acid secretion in the stomach. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an inhibitor of H+/K+-ATPase. The multibinding compounds of this invention are useful in the treatment gastroesophageal reflux disease ("GERD").

L'invention concerne des composés multiliaisons qui inhibent la H?+¿/K?+¿-ATPase, une enzyme qui intervient dans la régulation de la sécrétion d'acide dans l'estomac. Les composés multiliaisons de l'invention contiennent de 2 à 10 ligands fixés de manière covalente à un ou à plusieurs lieurs. Chaque ligand constitue un inhibiteur de H?+¿/K?+¿-ATPase. Les composés multiliaisons de l'invention sont utiles dans le traitement de reflux gastro-oesophagien pathologique (RGO).

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