Inhibitors of hepatitis c virus

Details Inhibitors of hepatitis c virus Inhibitors of hepatitis c virus

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01)

Patent

CA 2582095

The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope glycoprotein of hepatitis C virus has previously undescribed domains that are important for interactions with cellular or viral proteins that are necessary for early steps in HCV infection. . The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by hepatitis C virus and related viruses.

L'invention porte sur des procédés consistant à utiliser des peptides ou des dérivatifs de peptides pour inhiber l'infection par le virus de l'hépatite C. Cette invention repose en partie sur la découverte selon laquelle la glycoprotéine d'enveloppe E2 du virus de l'hépatite C présente des domaines non décrits jusqu'à présent qui sont essentiels dans les interactions avec les protéines cellulaires ou virales nécessaires pour anticiper l'infection VHC. L'invention concerne des peptides, des procédés de traitement et la prophylaxie de maladies induites par le virus de l'hépatite C et par des virus apparentés.

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