Inhibitors of hepatitis c virus rna-dependent rna...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2516235

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).

L'invention concerne des composés représentés par la formule (1), ainsi que des sels, solvates, promédicaments et métabolites pharmaceutiquement acceptables de ces composés. W, Z, R?1¿ et R?2 ¿sont tels que définis dans le descriptif. L'invention concerne également des méthodes de traitement du virus de l'hépatite C chez les mammifères, comprenant l'administration des composés représentés par la formule (I), et des compositions pharmaceutiques destinés au traitements de telles pathologies, qui contiennent les composés représentés par la formule (I). L'invention concerne en outre des procédés permettant de préparer les composés représentés par la formule (I).

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