C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/351 (2006.01) A61K 31/366 (2006.01) A61P 31/14 (2006.01) C07D 309/32 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2577525
The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
La présente invention concerne des composés représentés par la formule (4) et des sels et des solvates de ces composés répondant aux normes pharmaceutiques, qui conviennent comme inhibiteurs de la polymérase du virus de l'hépatite C (VHC) et qui convienne aussi pour le traitement des infections par le VHC chez des mammifères infectés par ce virus. Cette invention concerne aussi des compositions pharmaceutiques comprenant ces composés, des sels et de solvates de ces composés répondant aux normes pharmaceutiques. Cette invention concerne enfin des composés intermédiaires et des techniques qui conviennent pour la préparation des composés représentés par la formule (4).
Gonzalez Javier
Jewell Tanya Michelle
Li Hui
Linton Angelica
Tatlock John Howard
Pfizer Inc.
Smart & Biggar
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