C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/00 (2006.01) A61K 31/4025 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61K 31/455 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 211/00 (2006.01) C07D 213/81 (2006.01) C07D 239/42 (2006.01) C07D 241/26 (2006.01) C07D 333/38 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 405/02 (2006.01) C07D 409/00 (2006.01) C07D
Patent
CA 2484065
The invention concerns a compound of the formula (I); wherein Ring A is heterocyclyl; m is 0-4 and each R1 is a group such as hydroxy, halo, trifluoromethyl and cyano; Ring B is ring such as thienyl, thiadiazolyl, thiazolyl, pyrimidyl, pyrazinyl, pyridazinyl and pyridyl; R2 is halo and n is 0-2; and each R4 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by histone deacetylase.
L'invention concerne des composés de formule (I), dans laquelle le noyau A désigne un hétérocyclyle; m est égal à 0 4 et chaque R?1¿désigne un groupe tel que hydroxy, halo, trifluorométhyle and cyano; le noyau B désigne un noyau tel que thiényle, thiadiazolyle, thiazolyle, pyrimidyle, pyrazinyle, pyridazinyle et pyridyle; R?2¿ désigne un halo et n est égal à 0 - 2; chaque R?4¿ désigne un groupe tel que hydroxy, halo, trifluorométhyle et cyano; p est égal à 0 - 4; et R?3 ¿désigne un amino ou un hydroxy; ou des sels pharmaceutiquement acceptables ou un ester hydrolysable <u>in-vivo</u> ou un amide desdits composés. L'invention concerne en outre des procédés de préparation de ces composés, des compositions pharmaceutiques les renfermant, et leur utilisation dans le traitement de maladies ou de troubles médicaux dont l'origine est attribuée à l'histone déacétylase.
Gibson Keith Hopkinson
Stokes Elaine Sophie Elizabeth
Waring Michael James
Astrazeneca Ab
Fetherstonhaugh & Co.
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