C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/343 (2006.01) A61K 31/36 (2006.01) A61K 31/40 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61K 31/455 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) A61K 31/5377 (2006.01) C07D 209/14 (2006.01) C07D 277/68 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2559733
The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.
La présente invention a trait à une série de composés utiles pour l'inhibition de l'activité enzymatique d'histone désacétylase (HADC). L'invention a également trait à un procédé pour l'inhibition d'histone désacétylase dans une cellule mettant en oeuvre lesdits composés ainsi qu'à un procédé pour le traitement de maladies et de conditions de la prolifération cellulaire mettant en oeuvre lesdits inhibiteurs d'histone désacétylase. L'invention a trait en outre à des compositions pharmaceutiques comportant des composés inhibiteurs d'histone désacétylase et un support pharmaceutiquement acceptable.
Bouchain Giliane
Delorme Daniel
Frechette Sylvie
Gaudette Frederic
Isakovic Ljubomir
Mbm Intellectual Property Law Llp
Methylgene Inc.
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