Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

C

C07C 259/10 (2006.01) A61K 31/16 (2006.01) C07C 311/21 (2006.01) C07D 271/12 (2006.01)

Patent

CA 2573369

The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases. Further, the compounds of the present invention have antiprotozoal properties.

La présente invention concerne des dérivés de l'acide hydroxamique qui sont des inhibiteurs de l'histone désacétylase (HDAC). Les composés de la présente invention sont utiles pour traiter des maladies prolifératives des cellules, dont le cancer. En outre, les composés de la présente invention sont utiles pour traiter des maladies neurodégénératives, la schizophrénie et l'attaque entre autres maladies. En outre, les composés de la présente invention ont des propriétés antiprotozoaires.

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