Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

C

C07C 235/84 (2006.01) A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07C 233/80 (2006.01) C07C 237/40 (2006.01) C07C 311/19 (2006.01) C07D 209/16 (2006.01) C07D 209/44 (2006.01) C07D 211/22 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/50 (2006.01) C07D 213/74 (2006.01) C07D 239/46 (2006.01) C07D 249/14 (2006.01) C07D 277/82 (2006.01) C07D 295/14 (2006.01) C07D 295/155 (2006.01) C07D 295/18 (2006.01) C07D 29

Patent

CA 2501265

The invention provides compoods and methods for treating cell proliferative- diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, excipient, or diluent, and methods of using the compounds to inhibit cellular proliferation in vitro and therapeutically.

L invention concerne des composés et des méthodes permettant de traiter des maladies à prolifération cellulaire. L'invention concerne également de nouveaux inhibiteurs de l'activité enzymatique de l'histone déacétylase, des compositions à base des composés comprenant lesdits inhibiteurs, un porteur, un excipient ou un diluant pharmaceutiquement acceptable, et des méthodes d'utilisation de ces composés pour inhiber la prolifération cellulaire in vitro et thérapeutique.

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