Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/16 (2006.01) A61K 31/381 (2006.01) A61K 31/415 (2006.01) C07C 259/10 (2006.01) C07C 311/16 (2006.01) C07D 231/14 (2006.01) C07D 267/18 (2006.01) C07D 277/56 (2006.01) C07D 333/20 (2006.01) C07D 333/70 (2006.01) C07D 413/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2703718

This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.

La présente invention concerne des composés et des procédés pour l'inhibition de l'activité enzymatique de l'HDAC. Plus particulièrement, l'invention a trait à des composés de la formule (I), (I) et N-oxydes, des hydrates, des solvates, des sels pharmaceutiquement acceptables, des promédicaments et des complexes de ceux-ci, et des mélanges racémiques et scalémiques, des diastéréo-isomères et des énantiomères de ceux-ci. L, M, n, R, W, X et Y sont tels que définis dans la spécification.

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