Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 207/09 (2006.01) C07D 207/14 (2006.01) C07D 211/58 (2006.01) C07D 213/78 (2006.01) C07D 217/02 (2006.01) C07D 239/42 (2006.01) C07D 295/14 (2006.01) C07D 295/155 (2006.01) C07D 295/26 (2006.01) C07D 307/68 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01) C07D 471/10 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2476065

This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Cette invention a trait à de nouveaux composés correspondant à la formule (I), formule dans laquelle n, R?1¿, R?2¿, R?3¿, R?4¿, Q, X, Y, Z et ?_(A)¿ ont des significations définies. Ces nouveaux composés ont une activité enzymatique inhibant l'histone déacétylase. L'invention porte également sur leur préparation, sur des compositions les contenant ainsi que sur leur utilisation comme produit médicinal.

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