Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

A - Human Necessities

61

K

A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2558243

Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.

L'invention concerne des composés qui inhibent l'activité enzymatique de l'histone désacétylase (HDAC). L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés ainsi que des procédés permettant de traiter des états pathologiques, en particulier des états pathologiques proliférants, médiés au moins en partie par l'HDAC.

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