A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/19 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2531107
The present invention relates to the use of compounds acting as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, the invention relates to the use of such compounds for a suppressive therapeutic approach - the SUPPRESSION THERAPY - in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, the invention includes the manufacture of a clinically used medicament for the SUPPRESSION THERAPY of such inherited predisposing conditions.
La présente invention concerne l'utilisation de composés inhibiteurs d'enzymes à activité histone désacétylase dans le traitement thérapeutique d'états prédisposant un individu à developper une maladie, par exemple, entre autres, le cancer et les maladies inflammatoires ou métaboliques. Ces états sont associés à des mutations génétiques héréditaires de gènes essentiels prédisposant un individu présentant cet état à développer le phénotype de la maladie. L'invention concerne ainsi l'utilisation de ces composés dans une approche thérapeutique suppressive - la thérapie de suppression destinée à inhiber ou à retarder l'apparition ou la progression d'un trouble associé à une prédisposition génétique. L'invention concerne, de plus, la fabrication d'un médicament utilisé à des fins cliniques dans la thérapie de suppression desdits états de prédisposition héréditaire.
Hentsch Bernd
Hoevelmann Sascha
Martin Elke
Maurer Alexander B.
Raab Monika
Goudreau Gage Dubuc
Topotarget Germany Ag
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