Inhibitors of human phosphatidyl-inositol 3-kinase delta

Details Inhibitors of human phosphatidyl-inositol 3-kinase delta Inhibitors of human phosphatidyl-inositol 3-kinase delta

C - Chemistry, Metallurgy

07

D

C07D 473/38 (2006.01) A61K 31/517 (2006.01) A61K 31/52 (2006.01) A61P 7/00 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) C07D 239/00 (2006.01) C07D 249/00 (2006.01) C07D 403/12 (2006.01) C07D 473/00 (2006.01) C07D 473/16 (2006.01) C07D 473/24 (2006.01) C07D 473/30 (2006.01) C07D 473/34 (2006.01) C07D 473/40 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2406278

Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K.delta. plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K.delta., while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K.delta. activity, including compounds that selectively inhibit PI3K.delta. activity. Methods of using PI3K.delta. inhibitory compound s to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K.delta. inhibitory compounds to inhibit PI3K.delta.- mediated processes in vitro and in vivo.

L'invention concerne d'une part, des méthodes permettant d'inhiber l'activité de l'isoforme delta de la phosphatidylinositol 3-kinase (PI3K.delta.delta) et d'autre part, des méthodes de traitement de maladies, telles que les troubles de l'immunité et l'inflammation, où la PI3K.delta.delta joue un rôle dans la fonction des leucocytes. De préférence, lesdites méthodes utilisent des agents actifs qui inhibent sélectivement la PI3K.delta.delta, sans inhiber sensiblement l'activité des autres isoformes de PI3K. L'invention concerne également des composés qui inhibent l'activité de PI3K.delta.delta, notamment des composés qui inhibent sélectivement l'activité de PI3K.delta.delta. L'invention concerne, en outre, des méthodes d'utilisation de ces composés inhibant PI3K.delta.delta dans l'inhibition de la croissance ou de la prolifération des cellules cancéreuses, et donc des méthodes d'utilisation des composés inhibant PI3K.delta.delta dans l'inhibition de processus <i>in vitro</i> et <i>in vivo</i> à médiation PI3K.delta.delta.

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