Inhibitors of human phosphatidyl-inositol 3-kinase delta

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) C07D 403/08 (2006.01) C07D 403/12 (2006.01) C07D 487/02 (2006.01)

Patent

CA 2716334

Compounds that inhibit PI3K.delta. activity, including compounds that selectively inhibit PI3K6 activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K6) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K.delta. plays a role in leukocyte function, using the compounds also are disclosed.

La présente invention concerne des composés inhibiteurs de l'activité de PI3Kd, y compris des composés d'inhibition sélective de l'activité de PI3Kd. L'invention concerne également des procédés d'inhibition de l'activité de l'isoforme de phosphatidyl-inositol 3-kinase delta (PI3Kd), et des procédés de traitement de maladies, tels que des troubles immunitaires et inflammatoires dans lesquelles la PI3Kd joue un rôle dans la fonction leucocytaire, mettant en uvre les composés.

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