Inhibitors of human plasmin derived from the kunitz domains

Details Inhibitors of human plasmin derived from the kunitz domains Inhibitors of human plasmin derived from the kunitz domains

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/57 (2006.01) C12N 9/68 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2180954

This invention relates to novel mutants of the first Kunitz domain (K1) of the human lipoprotein-associated coagulation inhibitor (LACI) which inhibit plasmin. The invention also relates to other modified Kunitz domains that inhibit plasmin and to other plasmin inhibitors.

L'invention concerne de nouveaux mutants du premier domaine de Kunitz (K¿1?) de l'inhibiteur humain de coagulation associé à la lipoprotéine (LACI) qui inhibent la plasmine. L'invention concerne également d'autres domaines de Kunitz modifiés qui inhibent la plasmine, et d'autres inhibiteurs de la plasmine.

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