C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/09 (2006.01) A61K 31/165 (2006.01) A61K 31/417 (2006.01) A61K 31/5375 (2006.01) A61P 35/00 (2006.01) C07C 235/48 (2006.01) C07D 207/10 (2006.01) C07D 211/06 (2006.01) C07D 295/13 (2006.01) C07D 401/02 (2006.01) C07D 405/02 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2511242
Pharmaceutical compositions containing organic compounds of formula (I) or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.
L'invention concerne des compositions pharmaceutiques contenant des composés organiques ou leurs sels, qui servent de modulateurs des chimiokines SDF-1 ou I-TAC. Ces composés et compositions sont utiles dans le traitement du cancer, notamment dans l'inhibition de la prolifération et de la croissance cancéreuse et de la métastéase. L'invention concerne également des procédés d'interférence avec la liaison de SDF-1 et/ou I-TAC au récepteur CCXCKR2 et le traitement du cancer à l'aide des composés et compositions pharmaceutiques de la présente invention.
Burns Jennifer
Mcmaster Brian E.
Melikian Anita
Schall Thomas
Wright John J.
Cassan Maclean
Chemocentryx Inc.
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