Inhibitors of iap

Details Inhibitors of iap Inhibitors of iap

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2730448

The invention provides novel compounds that are inhibitors of IAPs having the general formula: wherein X1, X2, X3, Y, A, R1, R2, R3, R4, R4', R5, R5', R6 and R6' are as described herein. The compouds of the invention may be used to induce apoptosis in cells (or sensitise cells to apoptosis) in which IAPs are overexpressed or otherwise implicated in resistance to normal apoptotic processes. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment cancers.

L'invention concerne de nouveaux composés qui sont des inhibiteurs d'IAP ayant pour formule générale : dans laquelle X1, X2, X3, Y, A, R1, R2, R3, R4, R4', R5, R5', R6 et R6' sont tels qu'il est décrit ici. Les composés de l'invention peuvent être utilisés pour induire une apoptose dans des cellules dans lesquelles les IAP sont surexprimées, ou impliquées d'une autre manière dans la résistance aux processus apoptotiques normaux (ou sensibiliser ces cellules à l'apoptose). Ainsi, les composés peuvent être fournis dans des compositions pharmaceutiquement acceptables et utilisés pour le traitement de cancers.

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