Inhibitors of iap

Details Inhibitors of iap Inhibitors of iap

C - Chemistry, Metallurgy

07

D

C07D 209/02 (2006.01) C07D 263/06 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2683392

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1 - M - U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3', R4, R4' and R5, are as described herein.

L'invention propose de nouveaux inhibiteurs de IAP qui s'utilisent en tant qu'agents thérapeutiques pour traiter des malignités, les composés ayant la formule générale U1 - M - U2, dans laquelle M est un groupe de liaison reliant de manière covalente R2, R3, R4 ou R5 de U1 à un groupe R2, R3, R4 ou R5 de U2 ; U1 et U2 ont la formule générale (I) et G, X1, X2, R2, R3, R3', R4, R4 et R5, sont tels que décrits par les présentes.

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