A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2624587
The present invention provides novel inhibitors of inflammation and methods for treating inflammation by using these inhibitors. More specifically, the present invention provides transcription inhibitors, i.e., peptide fragments derived from internal regions of the Cytomegalovirus (CMV) IE2 protein that can inhibit production of inflammatory cytokines, e.g., Interleukin 1 beta (IFN- l .beta.) and the methods for treating inflammatory diseases and CMV infection and related disorders, by using the IE2 fragments. An pharmaceutical composition comprising the transcription inhibitor are also provided.
L'invention concerne de nouveaux inhibiteurs de l'inflammation et des méthodes de traitement des inflammations par l'utilisation de ces inhibiteurs. L'invention concerne de manière plus spécifique des inhibiteurs de la transcription, qui sont des fragments peptidiques dérivés de régions internes de la protéine IE2 du cytomégalovirus (CMV), capables de bloquer la production de cytokines inflammatoires comme p. ex. l'interleukine 1 bêta (IFN-1.beta.), ainsi que des méthodes permettant de traiter les maladies inflammatoires et les infections CMV ainsi que les troubles associés, par l'administration de ces fragments d'IE2. L'invention concerne en outre une composition pharmaceutique contenant cet inhibiteur de transcription.
Auron Philip E.
Listman James
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Research Foundation Of State University Of New York
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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