C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 27/02 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2520121
The present invention provides methods that enable the user to identify inhibitors of tissue granulation in and around a wound site, thereby limiting excessive scar formation as the wounded tissue heals. The some granulation inhibitors identified using the methods of the invention inhibit granulation in and around a wound site up to five fold, with a corresponding decrease in the formation of scar tissue when tested on retinal injuries. Granulation inhibitors that can be identified using the methods of the present invention include antibodies, peptides, nucleic acids (aptamers), and non-peptide small molecules.
L'invention concerne des procédés qui permettent à un utilisateur d'identifier des inhibiteurs de granulation tissulaire dans et autour d'un site de blessure, ce qui permet de limiter la formation excessive de cicatrices à mesure que les tissus endommagés guérissent. Les inhibiteurs de granulation identifiés au moyen desdits procédés permettent de multiplier par cinq l'inhibition de granulation dans et autour d'un site de blessure et d'entraîner une diminution correspondante de formation de tissus cicatriciels, ces résultats étant obtenus lors de tests menés sur des lésions rétiniennes. A titre d'inhibiteurs de granulation pouvant être identifiés par lesdits procédés, on trouve des anticorps, des peptides, des acides nucléiques (aptamères), et des petites molécules non peptidiques.
Jeffry Ursula
Johnson Dale E.
Facet Biotech Corporation
Protein Design Labs Inc.
Smart & Biggar
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