C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/023 (2006.01) A61K 31/395 (2006.01) A61K 38/04 (2006.01) C07D 213/75 (2006.01) C07D 233/90 (2006.01) C07D 243/06 (2006.01) C07D 403/06 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07K 5/02 (2006.01) C07K 5/04 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2192089
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1.beta. converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
L'invention concerne de nouvelles catégories de composés qui sont des inhibiteurs de l'enzyme de conversion d'interleukine-1 beta . Ces inhibiteurs possèdent des caractéristiques structurelles et physicochimiques spécifiques. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés. Ces composés et ces compositions pharmaceutiques sont particulièrement bien appropriés pour inhiber l'activité de l'enzyme de conversion d'interleukine-1 beta (ICE) et, par conséquent, peuvent s'utiliser avantageusement en tant qu'agents contre des maladies provoquées par interleukine-1, y compris des maladies inflammatoires, des maladies autoimmunes et des maladies neurodégénératives. Elle concerne également des procédés d'inhibition de l'activité de ICE, ainsi que des procédés de traitement de maladies provoquées par l'interleukine-1, au moyen desdits composés et desdites compositions.
Bemis Guy W.
Golec Julian M. C.
Lauffer David J.
Livingston David J.
Mullican Michael D.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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