Inhibitors of ion channels

Details Inhibitors of ion channels Inhibitors of ion channels

C - Chemistry, Metallurgy

07

D

C07D 277/52 (2006.01) A61K 31/41 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 25/04 (2006.01) C07D 231/42 (2006.01) C07D 249/04 (2006.01) C07D 249/14 (2006.01) C07D 257/06 (2006.01) C07D 261/16 (2006.01) C07D 277/56 (2006.01) C07D 285/08 (2006.01) C07D 285/135 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2681572

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

L'invention concerne des composés, compositions et procédés utiles dans le traitement d'une maladie par inhibition du flux d'ions sodium dans des canaux sodiques sensibles au voltage. Plus particulièrement, l'invention propose des arylsulfonamides substitués, des compositions comprenant ces composés ainsi que des procédés d'utilisation de ces composés et compositions dans le traitement de troubles du système nerveux central ou périphérique, plus spécifiquement de douleurs et de douleurs chroniques, en bloquant les canaux sodiques associés au départ ou à la récurrence des affections indiquées. Les composés, compositions et procédés décrits dans la présente invention trouvent une utilisation spécifique dans le traitement de douleurs neuropathiques ou inflammatoires par l'inhibition du flux ionique dans un canal sodique sensible au voltage.

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