C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/52 (2006.01) A61K 31/426 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2628312
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
La présente invention concerne des composés, compositions et procédés utiles dans le traitement de maladies par inhibition de courants d~ions sodium à travers les canaux sodiques sensibles au voltage. Plus particulièrement, la présente invention concerne des sulfonamides d~aryle substitués, des compositions comprenant ces composés, ainsi que des procédés d~utilisation de ces composés ou compositions dans le traitement de troubles du système nerveux central ou périphérique, particulièrement de la douleur et de la douleur chronique par blocage des canaux sodiques associé au début ou à la récurrence des maladies indiquées. Les composés, compositions et procédés selon la présente invention sont particulièrement utiles dans le traitement de la douleur inflammatoire ou neuropathique, par inhibition du courant d~ions à travers les canaux sodiques sensibles au voltage.
Beaudoin Serge
Fulp Alan
Marron Brian
Seconi Darrick
Suto Mark
Fetherstonhaugh & Co.
Icagen Inc.
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