C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61K 31/437 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2707491
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
La présente invention concerne des composés qui inhibent les quatre JAK kinases de mammifères connues (JAK1, JAK2, JAK3 et TYK2) et la PDK1. L'invention concerne également des compositions qui comprennent de tels composés d'inhibition et des procédés d'inhibition de l'activité des enzymes JAK1, JAK2, JAK3, TYK2 et PDK1 par l'administration du composé à un patient ayant besoin d'un traitement contre des troubles myéloprolifératifs ou le cancer.
Lim Jongwon
Machacek Michelle R.
Otte Ryan D.
Taoka Brandon Mitsuo
Young Jonathan R.
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Corp.
LandOfFree
Inhibitors of janus kinases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of janus kinases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of janus kinases will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1382124