C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/38 (2006.01) A61K 31/381 (2006.01) A61K 31/4436 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 35/00 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2730010
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
La présente invention concerne des composés qui inhibent les quatre kinases JAK mammifères connues (JAK1, JAK2, JAK3 et TYK2). Linvention concerne également des compositions comprenant lesdits composés inhibiteurs et des procédés permettant dinhiber lactivité de JAK1, JAK2, JAK3 et de TYK2 par ladministration du composé à un patient ayant besoin dun traitement de troubles myéloprolifératifs ou dun cancer.
de Almeida Gabriela
Haidle Andrew
Konrad Kaleen
Machacek Michelle
Wilson Kevin
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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