C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/4427 (2006.01) A61K 31/5377 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2719847
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
L'invention concerne des composés inhibant les 4 Janus kinases mammifères connues (JAK1, JAK2, JAK3 et TYK2) et PDK1. La présente invention concerne également des compositions comprenant ces composés inhibiteurs ainsi que des méthodes permettant d'inhiber l'activité de JAK1, JAK2, JAK3 et TYK2 et de PDK1 par administration du composé à un patient nécessitant un traitement contre des syndromes myéloprolifératifs ou un cancer.
Altman Michael D.
Haidle Andrew
Konrad Kaleen M.
Machacek Michelle R.
Zabierek Anna A.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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