Inhibitors of janus kinases

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/38 (2006.01) A61K 31/415 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/635 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2732038

The instant invention provides for compounds that inhibit the four known mammalian JAK1 kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

La présente invention porte sur des composés qui inhibent les quatre kinases JAK de mammifère connues (JAK1, JAK2, JAK3 et TYK2). L'invention porte également sur des compositions renfermant de tels composés inhibiteurs et sur des procédés d'inhibition de l'activité de JAK1, JAK2, JAK3 et TYK2 par l'administration du composé à un patient ayant besoin d'un traitement pour des troubles myéloprolifératifs ou un cancer.

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