C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4353 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2727928
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Composés inhibant les quatre kinases JAK de mammifère connues (JAK1, JAK2, JAK3 et TYK2). L'invention concerne également des compositions qui comprennent de tels composés inhibiteurs et des méthodes permettant d'inhiber l'activité de JAK1, JAK2, JAK3, TYK2 et PDK1 par l'administration de ces composés à un patient nécessitant un tel traitement pour des troubles myéloprolifératifs du cancer.
de Almeida Gabriela
Grimm Jonathan B.
Maccoss Rachel N.
Machacek Michelle
Romeo Eric
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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