C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/4436 (2006.01) A61P 35/00 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2690141
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
La présente invention concerne des composés qui inhibent les quatre kinases JAK mammifères connues (JAK1, JAK2, JAK3 et TYK2) et PDK1. L'invention concerne également des compositions comprenant de tels composés inhibiteurs et des procédés d'inhibition de l'activité de JAK1, JAK2, JAK3, TYK2 et PDK1 par l'administration du composé à un patient nécessitant d'un traitement pour des troubles myéloprolifératifs ou d'un cancer.
Altman Michael
Christopher Matthew
Grimm Jonathan B.
Haidle Andrew
Konrad Kaleen
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Corp.
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