C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61K 31/4375 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2679694
The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDKl. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDKl kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.
L'invention concerne des composés qui inhibent la tyrosine kinase JAK2 et/ou PDK1. L'invention concerne également des compositions comprenant de tels composés inhibiteurs, et des procédés d'inhibition de l'activité de la tyrosine kinase JAK2 et/ou de l'activité d'inhibition de la kinase PDK1 par l'administration du composé à un patient qui nécessite des soins ou la prévention de troubles associés à une myéloprolifération ou un cancer.
Altman Michael
Dinsmore Christopher
Guerin David J.
Jung Joon O.
Kattar Solomon
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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