Inhibitors of jnk

Details Inhibitors of jnk Inhibitors of jnk

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2722158

The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula (I), wherein m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1, and Z2 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.

L'invention porte sur des promédicaments d'inhibiteurs de la JNK et sur des méthodes, formulations, et compositions inhibant la JNK et traitant les troubles médiés par la JNK. Lesdits promédicaments tels que décrits ci-après présentent la formule (I) dans laquelle: m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1 et Z2 sont tels que définis dans la description. Les composés et compositions y étant décrits modulent l'activité de la JNK. L'invention porte également sur des méthodes et formulations inhibant la JNK et traitant les troubles médiés par la JNK et analogues avec lesdits composés, et sur des procédés d'élaboration desdits composés et des compositions correspondantes, tels que définis dans la description.

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