Inhibitors of jun n-terminal kinase

Details Inhibitors of jun n-terminal kinase Inhibitors of jun n-terminal kinase

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/381 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/427 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2751141

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure fur-ther provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

La présente invention concerne des inhibiteurs d'enzymes c-Jun N-terminal kinases (JNK) dotés d'une structure représentée par la formule suivante : ou un sel ou solvate de ceux-ci, où le cycle A, Ca, Cb, Z, R5, W et Cy sont définis dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés de la présente invention et des procédés de préparation et d'utilisation des composés et compositions de la présente invention, par exemple dans le traitement et la prévention de diverses affections, telles que la maladie d'Alzheimer.

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