C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/20 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) C07D 213/75 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2701959
The present invention relates to pyridines or pyrazines that inhibit kinases. In particular the compounds of the invention inhibit members of the class III PTK receptor family such as FMS (CSF-IR), c- KIT, PDGFR.beta., PDGFR.alpha. or FLT3 and KDR, SRC, EphA2, EphA3, EphA8, FLT1, FLT4, HCK, LCK, PTK5 (FRK), SYK, DDR1 and DDR2 and RET. The compounds of the invention are useful in the treatment of kinase associated diseases such as immunological and inflammatory diseases; hyperproliferative diseases including cancer and diseases involving neo-angiogenesis; renal and kidney diseases; bone remodeling diseases; metabolic diseases; and vascular diseases.
La présente invention concerne des pyridines ou des pyrazines qui inhibent les kinases. En particulier, les composés de l'invention inhibent des éléments de la famille des récepteurs PTK de la classe III, tels que FMS (CSF-IR), c-KIT, PDGFRß, PDGFRa ou FLT3 et KDR, SRC, EphA2, EphA3, EphA8, FLT1, FLT4, HCK, LCK, PTK5 (FRK), SYK, DDR1 et DDR2 et RET. Les composés de l'invention sont utiles dans le traitement de maladies associées à une kinase, telles que des maladies immunologiques et inflammatoires ; des maladies hyperprolifératives comprenant le cancer et des maladies mettant en jeu une néo-angiogenèse ; des maladies rénales et des reins ; des maladies de remodelage osseux ; des maladies métaboliques ; et des maladies vasculaires.
Burns Christopher John
Harte Michael Francis
Palmer James T.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ym Biosciences Australia Pty Ltd
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