Inhibitors of leaderless protein export

Details Inhibitors of leaderless protein export Inhibitors of leaderless protein export

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/15 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/27 (2006.01) A61K 31/38 (2006.01) A61K 31/382 (2006.01) A61K 31/52 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2281925

Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are provided. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta., CNTF and HIV-tat. These methods are useful in treatment of various conditions, including tumors and diabetes.

L'invention concerne des procédés permettant d'inhiber l'exportation d'une protéine dépourvue de séquence initiale provenant d'une cellule, par la mise en contact de la cellule avec un composé inhibant une liaison de la protéine dépourvue de séquence initiale avec une molécule transporteuse. Les protéines dépourvues de séquence initiale comprennent notamment FGF-1, FGF-2, IL-1.alpha., IL-1.beta., CNTF et VIH-tat. Les procédés sont utiles dans le traitement de diverses affections, notamment de tumeurs et de diabète.

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