C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/496 (2006.01)
Patent
CA 2514862
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures (Ia), (Ib) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
L'invention concerne des inhibiteurs de MIF utiles dans le traitement d'une palette de troubles, notamment le traitement d'états pathologiques associés à l'activité de MIF. Les inhibiteurs de MIF présentent les structures suivantes (Ia), (Ib) comprenant des stéréoisomères, des pro-médicaments et des sels acceptables sur le plan pharmaceutique de ceux-ci, dans lesquelles n, R¿1?, R¿2?, R¿3?, R¿4?, X et Z sont tels que définis dans la description. L'invention concerne également des compositions renfermant un inhibiteur de MIF conjointement avec un excipient acceptable sur le plan pharmaceutique, ainsi que des procédés d'utilisation de ceux-ci.
Kumar Sunil K. C.
Sircar Jagadish C.
Ying Wenbin
Avanir Pharmaceuticals
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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