C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C07K 5/00 (2006.01) C07K 5/02 (2006.01) C07K 5/072 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/113 (2006.01) C07K 5/117 (2006.01) C07K 7/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2241169
The present invention provides novel compounds comprising peptide sequences which mimic the conserved amino acid motif LDTSL of MAdCAM-1 and which have groups bonded to the N- and C-termini. Also provided are methods of inhibiting the interaction of a cell bearing a ligand of MAdCAM-1, such as human .alpha.4.beta.7, with MAdCAM-1 or a portion thereof (e.g., the extracellular domain), comprising contacting the cell with a compound of the present invention.
La présente invention concerne des nouveaux composés comprenant des séquences peptidiques imitant le motif aminoacide conservé LDTSL de MAdCAM-1, et possédant des groupes liés aux terminaisons N- et C-. On décrit également des procédés d'inhibition de l'interaction d'une cellule portant un ligand de MAdCAM-1, telle que la cellule humaine .alpha.4.beta.7, avec MAdCAM-1 ou avec une portion de celui-ci (par exemple le domaine extracellulaire), ce procédé consistant à mettre en contact cette cellule avec un composé de l'invention.
Schwender Charles F.
Shroff Hitesh N.
Leukosite Inc.
Millennium Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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