Inhibitors of malt1 proteolytic activity and uses thereof

Details Inhibitors of malt1 proteolytic activity and uses thereof Inhibitors of malt1 proteolytic activity and uses thereof

A - Human Necessities

61

K

A61K 38/07 (2006.01)

Patent

CA 2705694

The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO, and Z-GASR-CMK,and small compounds such as 5-{[5-(3-chloro-4-methylphenyl)-2- furyl]methylene}-2-thioxodihydro-4,6(1H,5H)--pyrimidinedione and variants thereof, and the use of those compounds for the preparation of a medicament. The invention relates further to a method to screen for inhibitors of the MALT1 proteolytic and/or autoproteolytic activity.

La présente invention concerne des inhibiteurs de l'activité protéolytique et/ou autoprotéolytique de MALT1. L'invention concerne plus spécifiquement des composés tels que, mais sans y être limités, des dérivés de peptides tels que Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO et Z-GASR-CMK, des petits composés tels que la 5-{[5-(3-chloro-4-méthylphényl)-2-furyl]méthylène}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione et ses variantes, et l'utilisation de ces composés pour la préparation d'un médicament. L'invention concerne également un procédé de criblage d'inhibiteurs de l'activité protéolytique et/ou autoprotéolytique de MALT1.

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