Inhibitors of mammalian collagenase

Details Inhibitors of mammalian collagenase Inhibitors of mammalian collagenase

C - Chemistry, Metallurgy

07

C

530/5, 260/525.1

C07C 51/58 (2006.01) C07C 51/08 (2006.01) C07C 51/367 (2006.01) C07C 51/377 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1180324

Abstract Mammalian collagenase is inhibited by compounds having the formula Image and salts thereof, wherein R1 is hydrogen or alkanoyl of 2 to 10 carbon atoms; R2 is hydroxy, amino, or Image R3 is hydrogen alkyl of 1 to 4 carbon atoms, Image or Image ; R4 is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and m is 0 or an integer of 1 to 9.

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