Inhibitors of mammalian collagenase and elastase

C - Chemistry – Metallurgy – 07 – D

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260/309.3

C07D 277/70 (2006.01)

Patent

CA 1262551

ABSTRACT OF THE DISCLOSURE There are disclosed [benzothiazolythio]phenylacetyl-L- cysteines having the formula Image wherein R1 is hydrogen, halo, nitro, amino, lower alkyl, lower alkoxy, trifluoromethyl or hydroxy; R2 is halo, lower alkyl, lower alkoxy, amino, nitro or trifluoromethyl and the pharmaco- logically acceptable salts thereof, a method of inhibiting mammalian elastase and collagenase by using the [benzothiazolyl- thio]phenylacetyl-L-cysteines and the pharmacologically accep- table salts thereof, and mammalian elastase and collagenase inhibiting compositions containing the [benzothiazoylthio] phenylacetyl-L-cysteines or the pharmacologically acceptable salts thereof.

496833

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