Inhibitors of melanocyte tyrosinase as topical skin lighteners

Details Inhibitors of melanocyte tyrosinase as topical skin lighteners Inhibitors of melanocyte tyrosinase as topical skin lighteners

A - Human Necessities

61

K

A61K 31/425 (2006.01) A61K 8/41 (2006.01) A61K 8/46 (2006.01) A61K 8/49 (2006.01) A61K 31/095 (2006.01) A61K 31/135 (2006.01) A61K 31/136 (2006.01) A61K 31/145 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/24 (2006.01) A61K 31/36 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/428 (2006.01) A61P 17/00 (2006.01) A61Q 19/02 (2006.01)

Patent

CA 2401336

Methods and formulations are provided to reduce pigmentation in skin, using an array of compounds selected from benzimidazoles, phenylthioureas, phenyltiols, phenylamines, bi- and multicyclic phenols, thiopheneamines, and benzothiamides. The compounds preferably inhibit pigment systhesis in melanocytes through the tyrosinase pathway. The methods can be used for lightening skin, and for treating uneven skin complexions which result from hyperpigmentation related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically.

L'invention concerne des méthodes et des formulations servant à réduire la pigmentation de la peau, au moyen d'un réseau de composés choisis dans le groupe constitué de benzimidazoles, de phénylthiourées, de phényltiols, de phénylamines, de phénols bicycliques et multicycliques, de thiophèneamines et de benzothiamides. De préférence, ces composés inhibent la synthèse pigmentaire dans les mélanocytes à travers la voie de la tyrosinase. Ces méthodes peuvent être utilisées pour éclaircir la peau et pour traiter des complexions cutanées irrégulières qui résultent d'une hyperpigmentation relative à des états pathologiques tels que les mélasmes, les taches de vieillesse, les taches de rousseur, l'ochronose et le lentigo. Ces composés peuvent être utilisés à des fins médicales ou cosmétiques.

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