C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/06 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2605510
The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.
La présente invention concerne des composés inhibiteurs des sécrétions microsomales des protéines et/ou des apolipoprotéines B (Apo B) de transfert des triglycérides. Ces composés peuvent être utilisés dans la prévention et le traitement de diverses maladies, en particulier l'athérosclérose et ses séquelles cliniques, dans la réduction des lipides sériques, et les troubles associés. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes de traitement des maladies telles que l'hypertriglycéridémie, l'hyperchylomicronémie, l'athérosclérose, l'obésité, et les états pathologiques associés à l'aide desdits composés. L'invention concerne également une méthode de réduction des sécrétions des apolipoprotéines B (apo B).
Bartolozzi Alessandra
Campbell A. Stewart
Foudoulakis Hope
Kim Enoch
Sweetnam Paul
Gowling Lafleur Henderson Llp
Surface Logix Inc.
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