Inhibitors of naaladase enzyme activity

Details Inhibitors of naaladase enzyme activity Inhibitors of naaladase enzyme activity

C - Chemistry, Metallurgy

07

F

C07F 9/28 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/66 (2006.01) A61K 31/662 (2006.01) A61K 38/55 (2006.01) A61K 45/00 (2006.01) A61P 13/08 (2006.01) A61P 35/00 (2006.01) C07D 209/04 (2006.01) C07D 213/16 (2006.01) C07D 307/34 (2006.01) C07D 333/04 (2006.01) C07F 9/22 (2006.01) C07F 9/30 (2006.01)

Patent

CA 2291258

The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N- Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.

La présente invention porte sur des inhibiteurs de dipeptidase, et plus spécifiquement, sur de nouveaux procédés d'utilisation de dérivés de phosphonate, d'hydroxyphosphinyle et de phosphoramidate pour inhiber l'activité enzymatique acidifiante de dipeptidase (NAALADase), et pour traiter les maladies de la prostate, notamment à l'aide des composés de la présente invention qui permettent d'inhiber la prolifération des cellules cancéreuses dans la prostate.

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