Inhibitors of neuraminidases

Details Inhibitors of neuraminidases Inhibitors of neuraminidases

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/357 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/5377 (2006.01) A61K 31/66 (2006.01) A61K 31/662 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) A61P 43/00 (2006.01) C07D 207/00 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 40

Patent

CA 2388859

Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

L'invention concerne des composés de formule (I), utilisés pour inhiber les neuraminidases de micro-organismes pathogènes, notamment la neuramidinase grippale. L'invention concerne également des compositions et des méthodes de prévention et de traitement de maladies causées par des micro-organismes comportant une neuraminidase, des procédés de préparation des composés, et des intermédiaires synthétiques utilisés dans ces procédés.

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