Inhibitors of nitric oxide biosynthesis

Details Inhibitors of nitric oxide biosynthesis Inhibitors of nitric oxide biosynthesis

C - Chemistry, Metallurgy

07

C

167/246, 260/469

C07C 281/16 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 38/05 (2006.01) C07C 243/36 (2006.01) C07C 271/08 (2006.01) C07C 271/24 (2006.01) C07C 271/60 (2006.01) C07C 279/00 (2006.01) C07C 279/14 (2006.01) C07C 281/02 (2006.01) C07C 281/06 (2006.01) C07K 5/062 (2006.01) C07K 5/068 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2036770

The present invention is directed to a new class of compound of the formula: Image in which X is represented by cyano, cyclopropyl, 2-propyne, 2,3- butadiene or NHR2, in which R2 is represented by H, -CF3, -CH2CF3, or C1-6 alkyl; R is represented by an amino acid or OM in which M is represented by H, C1-6 alkyl, benzyl, phenyl, pivoyl methyl ether, Z is represented by O or NR1, in which is represented by H, -CF3, -CH2CF3 or C1-6 alkyl; and W is represented by a substituent selected from the group consisting of -CH2-NH-, -(CH2)2-NH,-NH-NH-, -CH2-NH-NH-, -CH2-O-NH- and -O-NH-; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of the biosynthesis of nitric oxide.

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