Inhibitors of nitric oxide synthase

Details Inhibitors of nitric oxide synthase Inhibitors of nitric oxide synthase

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/00 (2006.01) A61K 31/155 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) C07C 233/36 (2006.01) C07C 233/78 (2006.01) C07C 237/24 (2006.01) C07C 257/14 (2006.01) C07C 271/20 (2006.01) C07C 279/12 (2006.01) C07C 335/08 (2006.01) C07C 335/32 (2006.01) C07D 207/333 (2006.01) C07D 211/58 (2006.01) C07D 215/56 (2

Patent

CA 2319474

Disclosed are multibinding compounds which inhibit nitric oxide synthases (NOSs), enzymes which form nitric oxide and L-citrulline from L-arginine. The multibinding compounds of this invention contain from 2 to 10 ligands covalently attached to one or more linkers. Each ligand binds to a nitric oxide synthase. The multibinding compounds of this invention are useful in the treatment of chronic inflammation, arthritis, sepsis and the like.

La présente invention concerne des composés à liaisons multiples pouvant inhiber les monoxydes d'azote synthétases (NOS), et des enzymes qui produisent le monoxyde d'azote et L-citrulline à partir de L-arginine. Ces composés à liaisons multiples contiennent entre 2 et 10 ligands liés par covalence à un ou à plusieurs segments de liaison. Chaque ligand se fixe à un monoxyde d'azote synthétase. Les composés à liaisons multiples de cette invention sont utilisés dans le traitement de l'inflammation chronique, de l'arthrite, de la septicémie et d'autres troubles analogues.

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