C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) C07H 19/052 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2480470
The present invention relates to compounds of the general formula (I) which are inhibitors of 5'-methylthioadenosine phosphorylases and 5'- methylthioadenosine nucleosidases (MTAP and MTAN), the invention also relates to the use of these compounds in treatment of diseases and infections including cancer, bacterial infections and parasitic infections, and to pharmaceutical compositions containing the compounds.
La présente invention concerne des composés représentés par la formule (I) qui sont des inhibiteurs des 5'-méthylthioadénosine phosphorylases et des 5'-méthylthioadénosine nucléosidases (MTAP et MTAN). Cette invention concerne également l'utilisation de ces composés dans le traitement de maladies et d'infections telles que le cancer, les infections bactériennes et les infections parasitaires, ainsi que des compositions pharmaceutiques contenant lesdits composés.
Evans Gary Brian
Furneaux Richard Hubert
Schramm Vern L.
Tyler Peter Charles
Albert Einstein College Of Medicine Of Yeshiva University
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Industrial Research Limited
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