C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/4402 (2006.01) A61K 31/5025 (2006.01) A61P 9/10 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 489/04 (2006.01)
Patent
CA 2403828
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli, having the formula (III), or tautomers thereof or pharmaceutically acceptable salts thereof, wherein: each of Q1 and Q2 are independently selected from 5-6 membered aromatic carbocyclic or heterocyclic ring systems, or 8-10 membered bicyclic ring systems comprising aromatic carbocyclic rings, aromatic heterocyclic rings or a combination of an aromatic carbocyclic ring and an aromatic heterocyclic ring. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne des inhibiteurs de P38, une protéine kinase mammalienne intervenant dans la prolifération cellulaire, la mort cellulaire et la réponse à des stimulations extracellulaires. Elle concerne en outre des méthodes de production desdits inhibiteurs, des compositions pharmaceutiques contenant ces inhibiteurs, et des méthodes d'utilisation desdites compositions pour le traitement ou la prévention de divers troubles.
Bemis Guy
Evindar Ghotas
Salituro Francesco
Smart & Biggar
Vertex Pharmaceuticals Incorporated
LandOfFree
Inhibitors of p38 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of p38, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of p38 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1396469