Inhibitors of p38

Details Inhibitors of p38 Inhibitors of p38

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2339253

The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

La présente invention concerne des inhibiteurs de p38, une protéine kinase de mammifère intervenant dans la prolifération cellulaire, la mort cellulaire et la réponse à des stimuli extracellulaires. L'invention concerne également des techniques de production de ces inhibiteurs, des compositions pharmaceutiques renfermant ces inhibiteurs, et des méthodes d'utilisation de ces compositions dans le traitement et la prévention de diverses affections.

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